|
rs72613567
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conclusion: High risk of fatty liver disease amplifies the ALT-lowering effect of HSD17B13 rs72613567:TA in the Danish general population.
|
31155741 |
2020 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Previously, we identified a variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that is strongly associated with FLD, but the mechanistic basis for the association remains elusive.
|
31019090 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In patients without, but not in those with NASH, significant fibrosis was associated with steatosis grade and the PNPLA3 I148M variant.
|
30708111 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The risk of either NASH or F ≥ 2 fibrosis progressively increased with increasing PIIINP levels (P < .0001), independent of age, gender, adiposity measures, insulin resistance, NAS score and the patatin-like phospholipase domain-containing protein-3 rs738409 polymorphism.
|
31436362 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The progression of NAFLD, including nonalcoholic steatohepatitis (NASH), has a strong genetic component, and the most robust contributor is the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 encoding the 148M protein sequence variant.
|
30772256 |
2019 |
|
rs641738
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound <i>O</i>-acyltransferase domain-containing 7 (<i>MBOAT7</i>) and transmembrane channel-like 4 (<i>TMC4</i>) that associate with increased risk of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcohol-related cirrhosis, and liver fibrosis in those infected with viral hepatitis (Buch et al., 2015; Mancina et al., 2016; Luukkonen et al., 2016; Thabet et al., 2016; Viitasalo et al., 2016; Krawczyk et al., 2017; Thabet et al., 2017).
|
31621579 |
2019 |
|
rs72613567
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, the rs72613567 A-INS allele reduces the risk of NASH and progressive liver damage and may become a therapeutic target.
|
30323112 |
2019 |
|
rs7946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Decreased liver PC content in individuals with the NASH is independent of PEMT V175M genotype and could be partly linked to decreased GNMT expression.
|
31199045 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A missense variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known.
|
29555681 |
2018 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs738409 and rs58542926 variants, but not rs641738, were associated not only with non-alcoholic steatohepatitis (NASH) (odds ratio [OR], 2.00; 95% confidence interval [CI], 1.46-2.73 and OR, 1.91; 95% CI, 1.04-3.51) but also with significant fibrosis (≥ F2) (OR, 1.53; 95% CI, 1.11-2.11 and OR, 1.88; 95% CI, 1.02-3.46) in NAFLD, even after adjustment for metabolic risk factors.
|
29193269 |
2018 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Logistic regression was used to test associations [OR (95% CIs)] between low BMD, and both NASH and PNPLA3 I148M genotypes.
|
30176114 |
2018 |
|
rs2228570
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggest that donors' VDR rs2228570 AA alleles may play a major role in low serum 25(OH)D regarding pathological FLD in recipients after LDLT.
|
29750155 |
2018 |
|
rs2228570
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs641738
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs738409 and rs58542926 variants, but not rs641738, were associated not only with non-alcoholic steatohepatitis (NASH) (odds ratio [OR], 2.00; 95% confidence interval [CI], 1.46-2.73 and OR, 1.91; 95% CI, 1.04-3.51) but also with significant fibrosis (≥ F2) (OR, 1.53; 95% CI, 1.11-2.11 and OR, 1.88; 95% CI, 1.02-3.46) in NAFLD, even after adjustment for metabolic risk factors.
|
29193269 |
2018 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction.
|
29750155 |
2018 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate analysis showed patients carrying the rs1800624 heterozygote genotype (AT) exhibited 2.36-fold increased risk of NASH (odds ratio (OR) = 2.36; 95% confidence interval (95% CI): 1.35-4.19) after adjusting for confounders.
|
29928018 |
2018 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the presented data indicate that the G-A-T-G haplotype containing minor allele at position -374 A and major allele at position -429T, 1704G, and G82S G could be regarded as a marker for NASH.
|
29928018 |
2018 |
|
rs2228530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction.
|
29750155 |
2018 |
|
rs4674344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs903361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>ADORA1</i> rs903361 associated with resolution of NASH (<i>p</i> = 0.0005) and change in the ballooning score among Caucasian and Hispanic patients (<i>p</i> = 0.0005).
|
30065651 |
2018 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
|
rs58542926
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Decreased liver production/secretion of VLDL, decreased cholesterol and TGs in VLDL/LDL particles in serum, and increased tyrosine levels identify possible mechanisms by which rs58542926-T exerts its effects on increasing risk of fatty liver disease, decreasing cardiovascular disease, and increasing diabetes risk, respectively.
|
28539357 |
2017 |
|
rs58542926
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Interestingly, patients harbouring the TM6SF2 rs58542926 T allele that predispose to NAFLD/NASH had higher LBP level.
|
28464257 |
2017 |
|
rs3480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In patients at risk for NASH [odds ratio (OR) = 0.64, 95% confidence interval (CI), 0.47 to 0.87; P = 0.005], and more so in the high-risk subgroup of those with impaired fasting glucose/diabetes (OR = 0.44, 95% CI, 0.26 to 0.74; P = 0.002), the rs3480 A>G variant was independently associated with protection from F2 to F4 fibrosis.
|
28472477 |
2017 |
|
rs8050136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |